Optimal low-dose metronomic chemotherapy and antiangiogenic activity
نویسندگان
چکیده
منابع مشابه
Antiangiogenic metronomic chemotherapy.
Accessible online at: www.karger.com/onk Fax +49 761 4 52 07 14 E-mail [email protected] www.karger.com Most of the phase I–II clinical studies performed up to now used ‘metronomic-like’ schedules of cytostatic agents, often administered using weekly schedules of vinca alkaloids, taxanes, anthracyclines or alkylating agents resulting, however, in high dose-density treatments. A rational ide...
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Chemotherapeutic drugs chronically administered to tumor-bearing mice, using a frequent schedule at doses substantially lower than the maximum tolerated dose (MTD) (i.e., metronomic dosing), can cause sustained and potent antiangiogenic effects by targeting the endothelial cells of newly growing tumor blood vessels. These effects appear to occur in the absence of an increase in the severity of ...
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ژورنال
عنوان ژورنال: Nature Clinical Practice Oncology
سال: 2005
ISSN: 1743-4254,1743-4262
DOI: 10.1038/ncponc0280